Neuroprotective role of vitamin D3 in colchicine-induced Alzheimerâ€TMs disease in rats

نویسندگان

  • Adham R. Mohamed
  • Gehan Y. Soliman
  • Cherine A. Ismail
  • Hazem F. Mannaa
چکیده

Abbreviations: Ab, amyloid beta; AD, Alzheimer’s disease; BBB, blood–brain barrier; BDNF, brain derived neurotrophic factor; CSF, cerebrospinal fluid; GPX, glutathione peroxidase; GR, glutathione reductase * Corresponding author. Tel.: +2

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Preconditioning Effect of Aerobic Exercise with Vitamin D3 Intake on VEGF Levels in 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Background and Objective: The purpose of this study was to investigate the preconditioning effect of aerobic exercise with vitamin D3 consumption on vascular endothelial growth factor (VEGF) level in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson’s disease. Materials and Methods: Forty-eight male rats weighing 250-300 g were randomly assigned to 6 groups: healthy control, Parkin...

متن کامل

Vitamin D3 Induces Gene Expression of Ox-LDL Scavenger Receptors in Streptozotocin-Induced Diabetic Rat Aortas: New Insight into the Role of Vitamin D in Diabetic Atherosclerosis

Background: Several lines of evidence suggest that oxidized LDL (Ox-LDL) scavenger receptors play a crucial role in the genesis and progression of diabetic atherosclerosis. This study aimed to elucidate the effect of vitamin D3 on gene expression of lectin-like oxidized LDL receptor-1 (LOX-1), scavenger receptor-A (SR-A), Cluster of Differentiation 36 (CD36), and Cluster of Differentiation 68 (...

متن کامل

تاثیر ویتامین D3 در جلوگیری از پیشرفت بیماری انسفالومیلیت خود ایمن تجربی در موشهای نژاد C57BL/6

    Background & Aim: Multiple sclerosis(MS) is a chronic autoimmune disease of unknown etiology affecting the central nervous system. The prevalence of MS is the highest where environmental supply of vitamin D is low. Some studies have shown a strong protective effect of vitamin D3 on experimental autoimmune encephalomyelitis(EAE) of MS model, but it is not known how it affects EAE. Vitamin D3...

متن کامل

اثر اولئوروپئین بر حافظۀ احترازی غیرفعال در مدل آلزایمر القاشده توسط کلشی‌سین در موش بزرگ آزمایشگاهی

Background and Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease along with learning and memory disorders. Oleuropein is a phenolic compound with antioxidant and neuroprotective properties that reduces oxidative stress and improves cognitive function. The purpose of this study was to investigate the effect of oleuropein pretreatment on the colchicine- induced cognit...

متن کامل

Protective Effect of Hydroethanolic Extract of Lippia citrodora L. Leaf and Vitamin D3 on Estradiol Valerate-Induced Polycystic Ovary Syndrome in Mice

Background and Objectives: This study was conducted to investigate the protective effect of hydroethanolic extract of Lippia citrodora L. leaf (LCE) and vitamin D3 on polycystic ovary syndrome (PCOS) in suri rats.   Methods: This experimental study was performed on 48 female suri rats with a weight range of 25-35g. The subjects were divided into 8 groups (n=6 each), namely control (food + wate...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015